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What happens if you are B-12 deficient but then have allergic response to cobalt? The supplements make me brake out into hives on the palms of my hands and the soles of my feet. Im in a bit of a pickle here.

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Lauren, Most reactions to b12 is to the flavoring, fillers, sweetners or other than the cobalamin itself. Try the Enzyamtic Therapy and Jarrow brands of methylb12. Also, paradoxical folate deficiency really hypes up allergic response. This may be telling you that you need a sizable dose of Metafolin. Deplin comes as 7.5mg and 15mg. Folate deficiency and mb12 deficiency causes hyper reactivness of every type especially allergy for many.

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Lauren, There have been some reports of allergy to nickel and cobalt, but they are not so well documented. Now the thing is that these allergies are to free cobalt, not to cobalt bound into the corin ring in vitamin B12. You may have a problem dealing with cyanide, which is in the cyanocobalamin supplements, also marketed as vitamin B12. You could try methylcobalamin and/or adenosylcobalamin. In these natural forms of vitamin B12, the cobalt is actually hidden in the molecule in a fashion that would be very hard for an antibody molecule to get to. The best way to tell would be to get the mix and put a small amount (a drop) on your skin and see if you get a reaction to the material. You can try the material from Womens Rodi HiTop Slippers Manas JwALDOl
(Red B12). Fredd is right about the material that is mixed with the vitamin B12 (the excipients), many people react to the salts etc, particularly in the cyanocobalamin (provitamin B12) form.

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Clive says

I have been having neurological symptoms + anxiety/depression for about 3-4 months.

The neurological symptoms have included pain, cramp and numbness in my feet and pains up my legs into my backside.

I have recently started on a course of 6 loading injections of hydroxocobalamin. I am also starting Freddd’s protocol. Is combining the two an overkill?

Considering the extent of my symptoms – how long before I can expect resolution of my neuropathy. My mental state is now quite a bit better after 3 injections.

Also what does the “nervous system waking” up feel like as compared with the nervous system deteriorating.

Cheers

Clive

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Research Article
Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish
Ana M. Vacaru , Antonio Fabio Di Narzo , Deanna L. Howarth , Orkhontuya Tsedensodnom , Dru Imrie , Ayca Cinaroglu , Salma Amin , Ke Hao , Kirsten C. Sadler
Disease Models Mechanisms 2014 7: 823-835; doi:10.1242/dmm.014472
Ana M. Vacaru
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Antonio Fabio Di Narzo
Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Deanna L. Howarth
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Orkhontuya Tsedensodnom
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Dru Imrie
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Ayca Cinaroglu
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Salma Amin
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Ke Hao
Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kirsten C. Sadler
Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, Box 1020, 1 Gustave L. Levy Place, New York, NY 10029, USA. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expression of hundreds of targets. UPR activation can result in outcomes ranging from enhanced cellular function to cell dysfunction and cell death. How this pathway causes such different outcomes is unknown. Fatty liver disease (steatosis) is associated with markers of UPR activation and robust UPR induction can cause steatosis; however, in other cases, UPR activation can protect against this disease. By assessing the magnitude of activation of UPR sensors and target genes in the liver of zebrafish larvae exposed to three commonly used ER stressors (tunicamycin, thapsigargin and Brefeldin A), we have identified distinct combinations of UPR sensors and targets (i.e. subclasses) activated by each stressor. We found that only the UPR subclass characterized by maximal induction of UPR target genes, which we term a stressed-UPR, induced steatosis. Principal component analysis demonstrated a significant positive association between UPR target gene induction and steatosis. The same principal component analysis showed significant correlation with steatosis in samples from patients with fatty liver disease. We demonstrate that an adaptive UPR induced by a short exposure to thapsigargin prior to challenging with tunicamycin reduced both the induction of a stressed UPR and steatosis incidence. We conclude that a stressed UPR causes steatosis and an adaptive UPR prevents it, demonstrating that this pathway plays dichotomous roles in fatty liver disease.

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Knowing how to create a Facebook business page correctly is essential when promoting your business. The most important part of making your Facebook page for business is selecting the business type that best fits your business ( Mens GelResolution 7 Tennis Shoes Asics iv55qp4K
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Step By Step Instructions for Creating a Facebook Page for Business

To begin, go to Facebook.com and on the bottom right you will see a link “create a page”. Next you will need to choose the type of page that best matches your business type. Once you have chosen the type of page you would like to create, Facebook will ask you to specify the category of your business. If you click around you will see that the only type of page that allows you to put in a local business address is the Local Business or Place page. If your business goal is to get more customers to your store then this is the page type for you.

Be cautious when typing in the name of your business, as this will become the title of your page. When a fan, friend, or potential customer is searching for your business the title of your page enables them to find your business. Facebook does not allow pages to be created with generic term only names such as “pizza” or “cars”. If you create a page with a generic term Facebook can change the page type to an un-editable community page which will no longer promote your business.

If you don’t have a personal profile, Facebook will create one for you in the process of setting up your business page. A personal profile is required for the use of many Facebook applications. Keep in mind that you can only have one personal profile and you must use your real name according to the Facebook terms of use.

Facebook will step you through completing the rest of the profile for your brand new business page, including choosing a profile picture, writing the About section, inviting your friends, and writing your first post. I recommend skipping inviting your friends and writing your first post until you have uploaded a cover photo (detailed below). The About section is particularly important as it will be the description of your business and its products or services. Keep in mind that the about section can only be 255 characters long. Complete all of the fields in the About tab.

You will also need to upload a cover photo to complete the look of your page. The Facebook cover is an opportunity for you to promote your brand identity and add visual impact to your page. Here is our Facebook cover photo for Decidedly Social. The optimum size for the cover photo is 851 pixels wide, 315 pixels tall and less than 100 kilobytes.

Once you have uploaded your cover, profile picture, and completed your About section you are ready to start posting updates and inviting friends. The next level of Facebook customization is using apps such as videos or contests to increase engagement with your fans. If you want to wait to begin posting updates until you have your apps in place, then I recommend changing your page visibility setting to Unpublish Page. To do this, click the edit page button at the top of admin panel and put a check in the top box and hit save.

A Mistake to Avoid When Promoting Your Business on Facebook

One mistake that many businesses make on Facebook is that they use a personal profile to promote their business. Don’t do this! It’s actually against the Facebook terms of use, which state that for personal profiles “You will not use your personal profile for your own commercial gain”. Facebook can delete your page for this behavior so I recommend against using your personal profile as your main channel of marketing on Facebook.

Small business social media , Social media marketing strategy , Social media platforms , Uncategorized
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When I talk to people about social media marketing, the overwhelming majority of people only think about Facebook. They think social media equals Facebook. Although that makes sense given the ubiquity and widespread adoption of this social network, it is NOT the only lemonade stand on the block! Social media has proliferated and evolved into many new shapes and forms and there might be some hidden gems waiting for you and your business.

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